On-Chip Integrated Antenna Structures for Biomedical Implantable Sensors

AbstractThis paper explores some different geometries of integrated antennas in a 0.35 μm CMOS technology for devices operating in theinternationally available unlicensed 2.4 GHz band. At this frequency, the wavelength is short enough to implement smallantennas with dimensions economically feasible for silicon integration.Two are the considered different families of structures: spiral and dipole antennas, and some different antenna structures (singleloop,4-loop, double-4-loop, dipole, bent-dipole, meander-dipole) are examined, all modeled and simulated in Ansoft HFSS.Their inductive and radiation characteristics are compared. Chip dimensions of the order of one square millimetre are considered

Local vs. Global Optimization for Optical Line System Control in Disaggregated Networks

Setting the operating point of optical amplifiers of optical line systems (OLS)s within transparent, disaggregated and reconfigurable networks is a crucial task that determines the optical transmission performance of the specific infrastructure. In this work, four optimization strategies for OLS control are compared through a simulation campaign, where a realistic physical layer is replicated using a machine-learning model derived from an experimental dataset on commercial devices for the Erbium-doped fiber amplifiers (EDFA)s and a characterized set of fiber spans. In particular, two distinct objective functions are evaluated, both at the end of the line (global approach), and, in turn, at the end of each single span (local approach)

Real-time Detection of Anthropic Events by 10G Channels in Metro Network Segments

We present an experimental proof-of-concept on detecting SOP variations including information on mechanical stresses on the network footprint by tapping out a small amount of power from 10G channels. Data can be gathered and classified locally, in each node, delivering alerts through streaming telemetr

Gain profile characterization and modelling for an accurate EDFA abstraction and control

Relying on a two-measurement characterization phase, a gain profile model for dual-stage EDFAs is presented and validated in full spectral load condition. It precisely reproduces the EDFA dynamics varying the target gain and tilts parameters as shown experimentally on two commercial items from different vendors

Experimental Demonstration of Partially Disaggregated Optical Network Control Using the Physical Layer Digital Twin

Optical communications and networking are fast becoming the solution to support ever-increasing data traffic across all segments of the network, expanding from core/metro networks to 5G/6G front-hauling. Therefore, optical networks need to evolve towards an efficient exploitation of the infrastructure by overcoming the closed and aggregated paradigm, to enable apparatus sharing together with the slicing and separation of the optical data plane from the optical control. In addition to the advantages in terms of efficiency and cost reduction, this evolution will increase network reliability, also allowing for a fine trade-off between robustness and maximum capacity exploitation. In this work, an optical network architecture is presented based on the physical layer digital twin of the optical transport used within a multi-layer hierarchical control operated by an intent-based network operating system. An experimental proof of concept is performed on a three-node network including up to 1000 km optical transmission, open re-configurable optical add & drop multiplexers (ROADMs) and whitebox transponders hosting pluggable multirate transceivers. The proposed solution is based on GNPy as the optical physical layer digital twin and ONOS as intent-based network operating system. The reliability of the optical control decoupled by the data plane functioning is experimentally demonstrated exploiting GNPy as open lightpath computation engine and software optical amplifier models derived from the component characterization. Besides the lightpath deployment exploiting the modulation format evaluation given a generic traffic request, the architecture reliability is tested mimicking the use case of an automatic failure recovery from a fiber cut

Dietary potassium intake and risk of diabetes : a systematic review and meta-analysis of prospective studies

(1) Background: Dietary potassium intake is positively associated with reduction of cardiovascular risk. Several data are available on the relationship between dietary potassium intake, diabetes risk and glucose metabolism, but with inconsistent results. Therefore, we performed a meta-analysis of the prospective studies that explored the effect of dietary potassium intake on the risk of diabetes to overcome these limitations. (2) Methods: A random-effects dose–response meta-analysis was carried out for prospective studies. A potential non-linear relation was investigated using restricted cubic splines. (3) Results: A total of seven prospective studies met the inclusion criteria. Dose–response analysis detected a non-linear relationship between dietary potassium intake and diabetes risk, with significant inverse association starting from 2900 mg/day by questionnaire and between 2000 and 5000 mg/day by urinary excretion. There was high heterogeneity among studies, but no evidence of publication bias was found. (4) Conclusions: The results of this meta-analysis indicate that habitual dietary potassium consumption is associated with risk of diabetes by a non-linear dose–response relationship. The beneficial threshold found supports the campaigns in favour of an increase in dietary potassium intake to reduce the risk of morbidity and mortality. Further studies should be carried out to explore this topic

Field clinical study evaluating the efficacy and safety of an oral formulation containing milbemycin oxime/praziquantel (Milbemax®, Novartis Animal Health) in the chemoprevention of the zoonotic canine infection by Dirofilaria repens

Dirofilaria repens is the causative agent of subcutaneous dirofilariosis of dogs, other animals and humans. This nematode is transmitted by mosquitoes of Aedes, Anopheles and Culex genera. In dogs, the parasite may cause subclinical infection or cutaneous signs. Recently, D. repens has emerged and spread in different geographical areas, with an increase of cases in dogs and humans. Chemoprevention in dogs in endemic areas is the most reliable approach for controlling this infection. This paper describes a randomized, blocked and multicentric clinical field study investigating the efficacy of an oral, chewable formulation containing milbemycin oxime/praziquantel (Milbemax®, Novartis Animal Health) in the chemoprevention of subcutaneous dirofilariosis in dogs. METHODS: This study was conducted in endemic areas of Italy. A total of 249 dogs, at two sites, negative for D. repens, were allocated into two groups (i.e. Treated -T1 vs Untreated-T2) with a ratio of 1:1, and subjected to clinical visits and blood sampling once monthly until the end of the study. All blood samples were microscopically and genetically examined. Animals belonging to T1 group received a minimum target dose of 0.5 mg/kg bodyweight of milbemycin oxime and 5 mg/kg of praziquantel in commercial tablets (Milbemax®) according body weight once every 4 weeks. Animals of group T2 were not treated with Milbemax® but received, when necessary, specific parasiticide treatments. The study duration was 336 ± 2 days for each dog. RESULTS: A total of 219 dogs completed the study (i.e. 111 in T1 and 108 in T2), while 30 dogs (i.e. 13 in T1, 17 in T2) were withdrawn for a variety of reasons unrelated to administration of Milbemax®. The percentages of animals not showing microfilariae of D. repens were 100% (111 animals) in T1 and 94.7% (108 animals out of 114) in group T2. Milbemax® was shown to be safe in treated dogs. CONCLUSIONS: The results of this study confirm that the monthly use of Milbemax® in dogs is effective and safe for the prevention of subcutaneous dirofilariosis in endemic areas